SIMULTANEOUS INTEGRATION OF GENE EXPRESSION AND NUTRIENT AVAILABILITY FOR STUDYING THE METABOLISM OF HEPATOCELLULAR CARCINOMA CELL LINES

Simultaneous Integration of Gene Expression and Nutrient Availability for Studying the Metabolism of Hepatocellular Carcinoma Cell Lines

How cancer cells utilize nutrients to support their growth and proliferation in complex nutritional systems is still an open question.However, it is certainly determined by both genetics and an read more environmental-specific context.The interactions between them lead to profound metabolic specialization, such as consuming glucose and glutamine an

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Adaptive optimisation of explosive reactive armour for protection against kinetic energy and shaped charge threats

We evaluate an adaptive optimisation methodology, Bayesian optimisation (BO), for designing a minimum weight explosive reactive armour (ERA) for protection against a surrogate medium calibre kinetic energy (KE) long rod projectile and surrogate shaped charge (SC) warhead.We perform the optimisation using a conventional BO methodology and compare it

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Organoids in the oral and maxillofacial region: present and future

Abstract The oral and maxillofacial region comprises a variety of organs made up of multiple soft and hard tissue, which are anatomically vulnerable to the pathogenic factors of trauma, inflammation, and cancer.The studies of this intricate entity have been long-termly challenged by a lack of versatile preclinical models.Recently, the advancements

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